Coordinate regulation of the human UDP-glucuronosyltransferase 1A10 gene by aryl hydrocarbon receptor (AhR) and nuclear factor erythroid 2-related factor 2 (Nrf2)

Introduction: UDP-glucuronosyltransferases (UGTs) catalyze an important metabolic process in which many xenobiotics and endobiotics are converted to water soluble compounds facilitating elimination from the body. UGT1A10 is capable of glucuronidating a number of phenolic compounds, steroids and benzo[a]pyrene, which are associated with carcinogenesis and inflammation. Aim of this study was the characterization of transcriptional regulation of the human UGT1A10 gene by the 2,3,7,8-tetrachlordibenzo-p-dioxin (TCDD) inducible transcription factor AhR and the tert-butyl hydroquinone (tBHQ) inducible factor Nrf2. Met…