CareLit Fachartikel
Interference with the p53 family network contributes to the gain of oncogenic function of mutant p53 in hepatocellular carcinoma (HCC)
AE Schulze Schleithoff, A Kairat, AF Koch, K Lorenz, W Stremmel, M Müller · Zeitschrift für Gastroenterologie · 2009 · Heft 01
Dokument
855776
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Jahr
2009
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Zusammenfassung
Introduction: Whereas the hallmark of wild-type (wt) p53 is its tumor suppressor activity, tumor-associated mutant p53 proteins can exert novel antiapoptotic gain of function activities, which confer a selective advantage upon tumor cells harboring such mutations. The p53 family members p63 and p73 give raise to proteins that have p53-agonistic as well as p53-antagonistic functions. p63 and p73 express two main classes of isoforms: isoforms which contain the transactivation domain (TAp73 and TAp63), executing transcriptional activity, and dominant negative isoforms which are truncated at the NH2-terminus acting…
Schlagworte
gain of function
hot-spot-mutants
p53
p63
p73
Zeitschrift für Gastroenterologie
