Thermal Ablation of Lung Tumors in an Ex-Vivo Human Model: Temperature Measurements and Vital Staining

Purpose: To evaluate in a human ex-vivo lung tumor model for thermal ablation whether temperature measurements and vital staining can provide information useful for therapy in patients. Materials and Methods: The study was approved by the local ethics committee. Increases in temperature induced by one or two laser fibers with diffuse tip were measured invasively in normal lung and tumors and compared with 2,3,5-triphenyltetrazolium chloride (TTC)-staining or histology. Resected specimens (native controls and thermally treated non-small cell lung cancers and normal lobes) were ventilated and perfused immediately…