The regulation between Human Endogenous Retroviral Syncytin and TGF-beta results in Proliferation or Cell-Cell Fusion of Endometrial Carcinoma

Endometrial carcinoma (EnCa) of endometrioid type mainly represents a steroid hormone driven tumor progression initiated from pre-stages. Due to the cell biological resemblance between the process of fetal blastocyst invasion and steroid hormone controlled growth into the maternal Endometrium and the development of tumor cells, we asked the question, if the human endogenous retrovirus (HERV)-W envelope gene, Syncytin, could be involved in the cell biology and tumorigenesis of endometrioid EnCa and its pre-clinical stages. Syncytin was found significantly increased at the mRNA and protein levels in EnCa and their…