Diffusion tensor imaging derived metrics and brain volume changes correlate with clinical progression in CADASIL: a serial MRI study in pure subcortical ischaemic vascular disease

Objective: CADASIL is monogenic microangiopathy leading to stroke and subcortical vascular dementia. MRI is sensitive in detecting preclinical involvement and changes over time. However, little is known about correlations between MRI parameters and clinical measures on a longitudinal scale. In this study we assessed the role of quantitative MRI (T2-lesion volume and diffusion tensor imaging derived metrics) in monitoring and predicting disease progression. Also, we determined the normalized brain volume and brain atrophy, which has recently been shown to be a clinically important marker of disease progression in…