Differential expression of excitatory amino acid transporters in relation to dopaminergic treatment and SIV specific pathology

Introduction: HIV-associated encephalopathy (HIVE) still remains a frequent complication in HIV-infection despite antiretroviral therapy and shares many clinical symptoms with Parkinson's disease. However, previous studies in the Simian immundeficiency virus (SIV) macaque model have shown that increased dopamine availibility does not result in symptomatic benefit like in Parkinson's disease but leads to acceleration of SIV encephalitis (SIVE) rather than neuroprotection. The aim of our study in the SIV model was to analyse the effect of various dopaminergic drugs and the NMDA antagonist memantine on the glutamat…