Sporadic hemiplegic migraine associated with a novel mutation in ATP1A2

Aims: Familial hemiplegic migraine (FHM) is a rare autosomal-dominant subtype of migraine with aura (MA) characterized by some degree of hemiparesis during the aura; so far, mutations in three genes (CACNA1A, ATP1A2 and SCN1A) have been identified in FHM pedigrees. In sporadic hemiplegic migraine (SHM) (i.e. hemiplegic migraine without a history of affected family members) the role of these genes is less clear. Previous series found mutations in CACNA1A only in a minority of cases, whereas no systematic data are available on ATP1A2 and SCN1A. Goals: To clarify the role of ATP1A2 in SHM. Patients and Methods: Ten…