Gene expression analysis of peripheral blood mononuclear cells from acute stroke patients
C. Grond-Ginsbach, T. Wiest, S. Horstmann, Y. Knyazev, U. Mansmann, M. Köhler, K. Pfleger, M. Hergenhahn, A. Grau, S. Wagner · Aktuelle Neurologie · 2006 · Heft 09
Bibliografische Angaben
Zusammenfassung
Background and purpose: Two studies have recently analyzed the gene expression profile of circulating cells in patients with acute ischemic stroke (Moore et al 2005; Tang et al 2006). Both studies presented lists of genes that were differentially expressed in white cells upon stroke. However, there was virtually no overlap between the findings of the two studies. Methods: We analyzed the expression profile of from peripheral blood mononuclear cells (PBMCs) and evaluated the expression of functional gene groups (not single genes). RNA from PBMCs of 20 acute stroke patients was analyzed with Affymetrix GeneChips.…
