PET-Imaging of a4ß2* nicotinic acetylcholine receptors in the central and peripheral nervous system
U. Wüllner, J. Bucerius, D. Gündisch, M. Minnerop, F. Jessen, A. Joe, T. Klockgether, H. Herzog, J. Schmaljohann · Aktuelle Neurologie · 2006 · Heft 09
Bibliografische Angaben
Zusammenfassung
Nicotinic acetylcholine receptors (nAChRs) contribute to a variety of brain functions and mediate the parasympathetic autonomic control of cardiac function. NAChRs assemble ligand-gated ion channels from at least 12 distinct subunits (a2- a10 and ß2-ß4) and function as monopentamers of a single subunit (e.g. a7) and heteropentamers (e.g. (a4ß2)- nAChR). The predominant nAChR in the CNS is the (a4ß2)-type. Comparatively few data are available on physiological functions and potential roles in neurological diseases. A reduction of different nAChR subtypes has been reported in post-mortem brains of patients with Alz…
