A new concept for prevention and treatment of prostate cancer with plant extracts or thereof derived substances

The Cimicifuga racemosa extract BNO 1055 (CR) inhibits proliferation of human prostate cancer-derived LNCaP cells. Therefore we tested the capability of this extract to inhibit formation and/or proliferation of tumors induced by subcutaneous (s.c.) inoculation of LNCaP cells in immunodeficient nu/nu mice. After inoculation of 1 mio cells 12 of 18 animals developed solid tumors while tumor development was seen in only 5 of 18 CR-treated animals of which the size at termination of the experiments 10 weeks after inoculation was significantly smaller than in the control animals. Upon histological inspection the amou…