MicroRNA expression profiling in Acute myeloid leukemia patients

AML is a heterogeneous disease characterized by rapid proliferation of myeloid cells and by various cytogenetic and molecular translocations. microRNAs, important novel regulators of gene activity, are involved in a wide variety of processes including apoptosis and cell differentiation. We asked if they could serve as biomarkers and therapeutic targets in AML. To thoroughly define the differenzial expression of microRNAs between defined groups of ALL and AML we performed microarray expression profiling of patient samples. ALL patient samples were included for comparison reasons. We demonstrate that primary patie…