CareLit Fachartikel

Oncogenic Potential of miR-125b-2 and its Target Genes in Normal and Malignant Hematopoesis

T Pushpanathan, J Klusmann, Z Li, K Böhmer, FJ Godinho, ML Koch, SH Orkin, D Reinhardt · Klinische Pädiatrie · 2009 · Heft 05

Dokument
858078
CareLit-ID
Jahr
2009
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Klinische Pädiatrie
Autor:innen
T Pushpanathan, J Klusmann, Z Li, K Böhmer, FJ Godinho, ML Koch, SH Orkin, D Reinhardt
Ausgabe
Heft 05 / 2009
Seiten
–
Erschienen: 2009-05-11 00:00:00
ISSN
0300-8630
DOI
10.1055/s-0029-1222671

Zusammenfassung

Children with Down Syndrome (DS) have increased risk for acute myeloid leukemia (AML), suggesting the presence of an additional copy of chromosome 21 is potentially oncogenic. We previously showed upregulation of chromosome 21 encoded miR-125b-2 in DS-AMKL. MiR-125b-2 increases the proliferation rate of hematopoietic stem and progenitor cells (HSPCs) while repressing myeloid differentiation, both in the murine and human system. Via integrative analyses of the transcriptome we identified a set of miR-125b-2 target genes in hematopoietic cells. Using Gene Set Enrichment Analysis (GSEA) we confirmed the downregulat…

Schlagworte

Klinische Pädiatrie