Lysine-Specific Demethylase 1 Is Strongly Expressed in Poorly Differentiated Neuroblastoma: Implications for Therapy
JH Schulte, A Schramm, T Thor, S Lim, K Pajtler, S Kuhfittig-Kulle, E Metzger, R Schuele, R Buettner, J Kirfel, A and Eggert · Klinische Pädiatrie · 2009 · Heft 05
Bibliografische Angaben
Zusammenfassung
Aberrant epigenetic changes are hallmarks of most cancers. Recently, a new class of histone modifying enzymes, demethylases, was identified catalyzing the removal of methyl groups from histone H3 lysine residues. Here, we address the functional significance of lysine-specific demethylase 1 (LSD1) in neuroblastoma. LSD1 expression correlated with adverse outcome and was inversely correlated with differentiation in neuroblastic tumors. Differentiation of neuroblastoma cells resulted in down-regulation of LSD1. Small interfering RNA-mediated knockdown of LSD1 decreased cellular growth, induced expression of differe…
