Proteomics of neuroblastoma master regulators

Neuroblastoma is the most common extracranial solid tumor of the early childhood and it originates from the sympathoadrenal lineage of the neural crest. Either its biological or its clinical behavior is very heterogenous ranging from spontaneous regression and rare genetic rearrangements in patients younger than one year to rapid progression and multiple genomic aberrations including gain of chromosome 17q, LOH of chromosome 1p and 11q and amplification of the MYCN protooncogene in older patients. Overexpression of the transcription factor MYCN leads to unregulated proliferation and growth of this tumors (Brodeu…