Characterization of the acid/base transporters in human gastric myofibroblasts

Background &Aims: Myofibroblasts are found subepithelially in many mucosal surfaces throughout the gastrointestinal tract. They play a central role in wound healing, repair of the extracellular matrix, epithelial proliferation and oncogenesis. Due to the large variety of functions, they can face different acid or alkali loads which can come either from its intrinsic metabolism or from an external source. Our aim was to characterize the intracellular pH (pHi) regulation of human myofibroblasts. Methods: Myofibroblasts were isolated from human gastric resection tissue. The cells were stained for alpha smooth muscl…