Role of Nogo-A in neuronal survival in the reperfused ischaemic brain

Nogo-A is an oligodendroglial neurite outgrowth inhibitor, the deactivation of which enhances brain plasticity and functional recovery in animal models of ischemic stroke and spinal cord trauma. A clinical trial with Nogo-A antibodies in spinal cord trauma is currently in progress. A clinical study in stroke is planned. All previous studies were carried out in permanent stroke models; we recently aimed to characterize the plasticity-promoting effects of Nogo-A-/- after transient focal cerebral ischemia. Strikingly, Nogo-A-/- mice submitted to 30min middle cerebral artery (MCA) occlusion revealed an increased mor…