Effectiveness, tolerability and changes in quality of life in patients with epilepsy treated with topiramate – results from a 28 weeks naturalistic study

Objectives: To explore tolerability, effectiveness and quality of life outcomes of patients with epilepsy treated with topiramate (TPM). Methods: Prospective, open label, single arm, non-interventional study (TOPMAT-EPY-0009) of 28 weeks duration (4 visits: day 0, approx. 4, 16 and 28 weeks) in patients ≥12 years with epilepsy. TPM was introduced after physician's decision was made if the baseline AED was regarded as in-effective/-tolerable and transition onto TPM monotherapy or TPM as initial monotherapy was planned. Measures included number of patients with continued TPM therapy, reason for initiation of TPM,…