CareLit Fachartikel

Safety and efficacy of rapidly i.v. titrated levetiracetam versus valproate in patients with partial epilepsy

A Hufnagel, S Limburg, S Evers, U Runge, U Schlegel, T Mayer, H Menger, W Heide, W Paulus · Aktuelle Neurologie · 2009 · Heft 10

Dokument
858372
CareLit-ID
Jahr
2009
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Aktuelle Neurologie
Autor:innen
A Hufnagel, S Limburg, S Evers, U Runge, U Schlegel, T Mayer, H Menger, W Heide, W Paulus
Ausgabe
Heft 10 / 2009
Seiten
–
Erschienen: 2009-10-07 00:00:00
ISSN
0302-4350
DOI
10.1055/s-0029-1238611

Zusammenfassung

The objective of this prospective, randomized, open-label study was to compare safety and efficacy of rapid titration of levetiracetam (LEV) versus valproate (VPA) (bid for 2 days) in patients with epilepsy or following an epileptic seizure. Method: A total of 61 patients (ages: 18–82 y; mean: 53 y; men: 35; women: 26) with diagnosed partial epilepsy or after a first seizure were included. Whereas 32 patients received 30mg/kg/d of LEV (min: 1400mg/d; max 3000mg/d, mean: 2218.4±394.4mg/d); 29 patients received 30mg/kg/d VPA (min: 1000mg/d; max: 2500mg/d; mean: 1696.6±353mg/d). The infusion time was 30 minutes. Af…

Schlagworte

Aktuelle Neurologie