The role of callosal volume as a MRI marker in subcortical ischaemic vascular dementia: a study in CADASIL

Background and purpose: Several studies demonstrate cortical neurodegeneration as an important factor of corpus callosum (CC) atrophy in Alzheimer's disease (AD) but little is known about the factors underlying CC volume loss in subcortical ischemic vascular dementia (SIVD). The aim of this study was to identify these factors and to determine the impact of CC volume on physical and cognitive impairment in CADASIL as a model of pure SIVD. Methods: 150 CADASIL subjects from an on-going prospective cohort were studied by MRI and clinical scales. The latter included the modified Rankin Scale (mRS), the Mattis Dement…