The protective effect of HLA-B27 in hepatitis C virus infection requires presence of a genotype-specific immunodominant CD8+ T cell epitope
C Neumann-Haefelin, J Timm, J Schmidt, K Fitzmaurice, S McKiernan, D Kelleher, D Huzly, M Roggendorf, HE Blum, R Thimme · Zeitschrift für Gastroenterologie · 2009 · Heft 09
Bibliografische Angaben
Zusammenfassung
Introduction: HLA-B27 is associated with protection in HIV and hepatitis C virus (HCV) infection. This protective role is linked to single immunodominant HLA-B27 restricted CD8+ T cell epitopes in both infections. Aim: In order to define the relative contribution of a specific HLA-B27 restricted epitope to the natural course of HCV infection, we compared the biological impact of the highly conserved HCV genotype 1 epitope, for which the protective role has been described, with the corresponding region in genotype 3 that differs in its sequence by three amino acid residues. Methods: The epitope-specific CD8+ T ce…
