Transcription regulators of hepatic heme-oxygenase-1 gene expression in IL-6 knock out mice: Comparison of two different models of acute phase reaction

Introduction: Heme-oxygenase-1 (HO-1) has a crucial role in maintaining body iron metabolism during acute phase response (APR). Its expression is principally regulated at transcriptional level, and involves complex intracellular pathways in response to external stimuli. IL-6 is one of principle mediators of APR and most of its signalling pathways, including the ones regulating HO-1 gene expression, involve STAT3 activation. In the current work, we aimed to investigate the main transcriptional regulators of HO-1 in IL-6 knock out mice using two different models of acute phase response. Methods: Male IL-6 knock-ou…