Characterization of a novel Modulator of the Wnt signaling pathway

The canonical Wnt-signaling pathway plays a crucial role during embryonic development, and maintains homeostasis of a variety of tissues, controls intestinal stem cell self-renewal, and regulates proliferation, morphology, and motility. It is the superior regulator of several parallel genetic programs coordinating development of the gastrointestinal tract. Deregulation of the canonical Wnt-signaling pathway is tightly associated with several cancers, in particular carcinogenesis in the gut. The specific contribution of the individual target genes of the pathway to the developmental and tumorbiological aspects in…