CareLit Fachartikel
Frischer Wind für Integrine
Susanne Kossatz, Johannes Notni · Der Nuklearmediziner · 2021 · Heft 02 · S. 152-159
Dokument
859118
CareLit-ID
Jahr
2021
Publikation
PDF
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Metadaten
DOI
ja
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Bibliografische Angaben
Zusammenfassung
AbstractToday, selective PET- and SPECT radiopharmaceuticals are not only available for αvβ3, but also for others of the 24 known integrin subtypes, including α5β1, αvβ6, αvβ8 und α6. These integrins are widely expressed by different carcinomas and in the course of fibrosis. Hence, integrin imaging offers a range of clinically relevant applications beyond imaging of angiogenesis. αvβ6 integrin radiopharmaceuticals, both diagnostic and therapeutic, have emerged as highly promising candidates for a clinical career, since αvβ6 is expressed by many malignant cancers, such as pancreatic, basal cell, squamous cell, lu…
Schlagworte
Integrine
Radiopharmaka
Molekulare Bildgebung
Pankreaskarzinom
Fibrose
Integrins
Radipharmaceuticals
Molecular imaging
Pancreatic carcinoma
Fibrosis
Der Nuklearmediziner
