CareLit Fachartikel
Using Dendritic Cells as therapeutic or prophylactic vaccine against HCV
F Voigt, K Weigand, C Eisenbach, B Hoyler, W Stremmel, J Encke · Zeitschrift für Gastroenterologie · 2007 · Heft 01
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860282
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Jahr
2007
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Zusammenfassung
Dendritic cells (DCs) are a promising tool for therapeutic and / or prophylactic vaccination experiments, considering their multiple functions in immune modulation. We used bone-marrow derived dendritic cells from BALB/c mice loaded with pseudo particles from the hepatitis C virus (HCVpp) to vaccinate native BALB/c mice. HCVpp consists of the two (genotype 1b) envelope proteins E1 and E2, covering a non-HCV core structure. Thus, not a single epitope, but the whole “viral surface“ induces immunogenicity. HCV E1/E2 pseudo particles were successfully established, demonstrated by dot blot and Huh–7 transduction assa…
Schlagworte
Dendritic cells
Hepatitis C
Virushepatitis
immunology
vaccine
Zeitschrift für Gastroenterologie
