Diagnostic criteria for acute liver failure

Aims: Wilson disease is an uncommon cause of acute liver failure. Early identification is crucial because of the high mortality without liver transplantation. Valid diagnostic criteria for acute liver failure due to Wilson disease have not been established. Methods: We compared findings of patients presenting with acute liver failure due to Wilson disease to those with acute liver failure of other etiologies. Results: Previously described criteria such as low alkaline phosphatase activity, low alkaline phosphatase to total bilirubin ratio or high AST to ALT ratio failed to identify patients with acute liver fail…