Immunization with Aerosols – State of the Art

Since its discovery in 1796 by Edward Jenner, vaccines have been an integral aspect of therapeutics, combating a number of infectious diseases with remarkable success. Although the currently available vaccines represent an outstanding success story in modern medicine and have had a dramatic effect on morbidity and mortality worldwide, it is clear that improvements are desirable in the current vaccine delivery technologies. Recent results indicate that the respiratory system, and the nasal mucosa in particular provide a valuable target site for immunisation against respiratory and mucosal pathogens. The storage a…