Congenic Iddm1 and Iddm2 homozygous WOKW.BB rats do not develop diabetes, but their (WOKW.4BB x BB/OK)F1 hybrids

Aim: WOKW rats develop facets of the metabolic syndrome and BB rats develop type 1 diabetes. Both strains are common the RT1u haplotype of major histocompatibility complex (MHC) which is essential for type 1 diabetes development in the BB rat termed Iddm1. However, BB rats need an additional gene to develop type 1 diabetes termed Iddm2 and identified as immune-associated nucleotide 4 (Ian4 or Gimap5). Because WOKW lacks Gimap5 and does not develop hyperglycemia a congenic WOKW rat strain was generated. Methods: The region of chromosome 4 with Iddm2 of BB/OK rats was introgressed into the genetic background of WO…