Familial autoinflammatory syndromes in the differential diagnosis of chronic abdominal pain

Familial autoinflammatory syndromes, including familial Mediterranean fever, are recently recognized group of disorders characterized by seemingly unprovoked inflammation but lacking high-titer autoantibodies. Genetic and clinical tools are improving the ability of the clinician to better approach patients with periodic fever and inflammation. The pathogeneses of many of these diseases are now understood to involve different aspects of a common pathway, largely affecting inflammatory cascades related to IL-1 or tumor necrosis factor-alpha (TNF-alpha). Here we report two cases, where patients were presented with…