Area postrema lesion potentiates selective and non-selective central and peripheral CRF2 receptor agonists-, Ucn 1 and Ucn 2-induced inhibition of gastric emptying

Aims: Area postrema (AP) located on the 4th brain ventricle's surface lacks normal blood-brain barrier (Van Houten et al. 1983) acts as chemoreceptor zone and has multiple neuronal connections to the nucleus of solitary tract (NTS), a regulatory key centre of gastrointestinal (GI) motility collecting afferent fibers from the GI tract. AP has also been proven to have role in regulation of gastric and colonic functions. Central Ucn 2, a CRF2 receptor agonist inhibits gastric emptying (GE) through sympathetic pathways. Aim: To characterize the role of AP in the peripheral and central CRF2 receptor peptide agonists-…