Functional characterization of the H+/K+ ATPase in wild type and gastrin knock-out mice
A Schnur, P Hegyi, V Venglovecz, Z Rakonczay, I Ignáth, T Takács, J Lonovics, A Varró, A Varró, G Dockray · Zeitschrift für Gastroenterologie · 2007 · Heft 05
Bibliografische Angaben
Zusammenfassung
Aims: It has been reported that gastrin knockout (GKO) mice are achlorhydric and importantly, fail to secrete acid in response to acute stimulation with exogenous histamin or gastrin (G17). However, a 6-day continuous infusion with G17 restores the capacity of parietal cells to secrete acid in response to both G17 and histamin indicating that parietal cells in GKO mice are not fully mature to respond to secretagoges without priming with G17. The aim of this study was to functionally characterize the H+/K+ ATPase in wild type (WT) and gastrin KO (GKO) mice and to investigate the effects of G17 on acid secretion i…
