The relation of thyroid hormone levels and reduced insulin sensitivity to survival of patients with septic shock

Muscular weakness frequently develops in the intensive care unit patients and it is associated with higher mortality rate. Oxidative phosphorylation produces energy and hypothyroidism produces a hypometabolic state. Studies have showed reductions of thyroid hormone levels in critical illness. We aimed to measure thyroid hormone levels in septic patients and investigate the relationship of these hormones with survival and inhibition of mitochondrial respiration. We determined representative mitochondrial enzyme gene transcript levels in vastus lateralis needle biopsy samples, using a real-time QPCR technique for…