The long-term effect of Helicobacter pylori eradication on the expression levels of COX-1 and -2, 5-LOX and leukotriene-receptors in human gastric mucosa

Introduction: H.pylori infection is a major risk factor for developing gastric cancer. Data about eradication of H.pylori and regression of gastric metaplasia or atrophy and gastric cancer prevention were inconsistent. Increased expression of Cyclooxygenase (COX)-2 was linked to intestinal type gastric cancer. Other related pathways have not been investigated so far. Methods: Prospective case-control study involving patients with a risk gastritis pattern but without advanced gastric metaplasia or atrophy; patients (n=12, each) with either successful (cases) or unsuccessful (controls) H.pylori eradication were ma…