Glycine pretreatment results in improved clinical outcome after extended partial hepatectomy

Aims: Glycine pre-treatment has recently been shown to improve the outcome after liver transplantation. Currently, it is not known whether glycine is also beneficial after extended (90%) partial hepatectomy (SH) and, if so, what molecular and cellular mechanisms may contribute to such an effect. Methods: 5 days prior to resection animals of the test group were fed with glycine treated chow. Male 6–8 weeks old Wistar rats (n=6/group) were subjected to SH. Postoperatively, relevant clinical data (liver-body-weight ratio, liver function tests, survival) were recorded. 24 hrs after surgery total RNA was isolated fro…