ALR expression indicates liver regeneration upon distinct tissue damage

Hepatocellular regeneration requires various factors promoting cellular proliferation. Among them, ALR (augmenter of liver regeneration), was discovered to be highly expressed in vivo under circumstances of liver regeneration and in liver diseases such as cirrhosis and carcinoma. Interestingly, ALR was shown to exhibit its action exclusively on regenerating livers and hepatoma cells. Therefore ALR is an interesting target to analyze liver regeneration. The aim of this study was to investigate the molecular regulation and expression of ALR in murine models of liver damage caused by tissue loss through 70% liver r…