Identification of RARRES1 as a key regulator in liver fibrosis

Genetic factors play important roles in the modulation of hepatic fibrosis and contribute to the variability in fibrosis progression. Thus, with the aim of targeting critical genes for therapeutic purposes, it is essential to identify key regulators of fibrosis development and discriminate them from collaterally regulated genes. In order to identify those key regulatory genes but also to possibly identify novel genes essential to liver fibrosis, we analysed a microarray dataset of liver fibrosis for differential gene regulation. We compared the genes identified to be differentially regulated in liver fibrosis to…