CareLit Fachartikel
The p53 family target gene signature is of prognostic relevance in hepatocellular carcinoma
F Staib, H Mundt, A Koch, M Krupp, PR Galle, W Stremmel, A Teufel, M Müller · Zeitschrift für Gastroenterologie · 2010 · Heft 01
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862496
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Jahr
2010
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Zusammenfassung
We have established that p53 and TAp63/TAp73 play a relevant role in hepatocarcinogenesis and in the therapeutic response of human hepatocellular carcinoma (HCC). Like p53, TAp63 and TAp73 activate genes that play roles in different steps of the apoptosis program. Accordingly, the therapeutic response/prognosis is not determined by p53 alone, but by the interactions between the different p53 family members. In order to investigate the prognostic relevance of the p53 family-dependent gene signature which we had obtained after transduction of Hep3B cells by rAd-p53, rAd-TAp63 or rAd-TAp73, we compared these in vit…
Schlagworte
HCC
bioinformatics
p53
p63
p73
survival prediction
Zeitschrift für Gastroenterologie
