A PNPLA3 polymorphism predisposing to NAFLD does not increase the risk of developing gallstones

Aims: Recently a genomewide scan has demonstraged that the adiponutrin (PNPLA3) coding polymorphism p.I148M markedly increases the risk of developing non-alcoholic fatty liver disease (NAFLD) [1]. Interestingly, insulin resistance already known to be strongly linked with the development of non-alcoholic steatohepatitis (NASH), has lately been showed to enhance the development of gallstones as well [2]. Herein we test whether the PNPLA3 p.I148M polymorphism in parallel increases the risk of developing gallstones. Patients and methods: Prospectively, we collected 229 individuals with gallstones (confirmed by ultra…