CYLD: A Key Regulator of Hepatocellular Apoptosis, Proliferation and Carcinogenesis
T Urbanik, S Heine, M Wörns, N Hövelmeyer, RJ Boger, BC Köhler, T Maass, R Massoumi, R Fässler, M Schuchmann, PR Galle, A Waisman, H Schulze-Bergkamen · Zeitschrift für Gastroenterologie · 2010 · Heft 01
Bibliografische Angaben
Zusammenfassung
Background and Aims: The tumor supressor CYLD is involved in NFκB and JNK signalling and cell cycle regulation. Full length CYLD (FLCYLD) counteracts NFκB activity and is a cellular adversary of the oncogene Bcl-3 (1). There is high evidence that short splice variant sCYLD positively regulates NFκB signal transduction and cellular homeostasis (2). The aim of our study was to analyse the role of CYLD for receptor mediated hepatocyte apoptosis, proliferation and chemically induced HCC development. Methods: We generated two mouse models for analysis of CYLD in hepatocytes. For the first model CYLD Exon7/8 flox/flox…
