Keratinocyte Growth Factor induces alveolisation in emphysematous mouse lungs via TGFβ-1

Rationale: Emphysema is characterized by destruction of alveoli and extracellular matrix (ECM) with ensuing airspace enlargement. Induction of alveolar and ECM regeneration is still a major challenge in emphysema therapy. Methods: Mice were therapeutically treated at three occasions by oropharyngeal aspiration of 10mg rHuKGF per kg body weight after induction of emphysema by porcine pancreatic elastase (PPE). Results: Airflow limitation associated with emphysema was largely reverse. PPE induced airspace enlargement and loss of alveoli were partially reversed as assessed by design-based stereology. The therapeuti…