TGF-β and hepatocyte transdifferentiation in liver fibrogenesis
S Dooley, J Hamzavi, L Ciuclan, P Godoy, I Ilkavets, S Ehnert, E Ueberham, R Gebhardt, R Gebhardt, S Kanzler, A Geier, K Breitkopf, HL Weng, PR Mertens · Zeitschrift für Gastroenterologie · 2008 · Heft 01
Bibliografische Angaben
Zusammenfassung
Dysregulated cytokine metabolism is a common feature of alcoholic liver disease and especially signaling of TGF-β is critical for progression of steatohepatitis to fibrosis. The profibrogenic role that TGF-β exerts in the liver has mostly been attributed to hepatic stellate cell activation and excess matrix synthesis. Hepatocytes are also highly responsive to TGF-β with increased apoptosis rates. However, in primary cell cultures and in vivo, the majority of cells survive despite activated TGF-β signaling. These display phenotypic changes and express proteins characteristic for epithelial mesenchymal transition…
