Genomic disruption of the Smad7 gene enhances CCl4 dependent liver damage and fibrogenesis in mice
S Ehnert, P Godoy, J Hamzavi, HL Weng, PR Mertens, S Kanzler, R Heuchel, S Dooley · Zeitschrift für Gastroenterologie · 2008 · Heft 01
Bibliografische Angaben
Zusammenfassung
TGF-β signaling is induced as a consequence of liver damage, triggering fibrogenesis in chronic disease. TGF-β effects are blunted by antagonistic Smad7, which is transiently induced upon initiation of TGF-β signaling in most cell types, providing negative feedback regulation, or by IFN-γ, TNF-α or EGF leading to a crosstalk of TGF-β with these pathways. We intoxicated viable S7ΔE1 mice bearing a deleted exon I in the endogenous smad7 gene, which had no adult liver phenotype, with CCl4, to analyse the impact of Smad7 to liver damage and fibrogenesis. Liver enzymes in serum after 8 weeks treatment consistently di…
