MiR–198 is under- and miR–122 is overexpressed in HCV-associated hepatocellular carcinomas
H Varnholt, M Tscheuschler, U Drebber, I Wedemeyer, P Schirmacher, HP Dienes, M Odenthal · Zeitschrift für Gastroenterologie · 2008 · Heft 01
Bibliografische Angaben
Zusammenfassung
Aims: Several studies in recent years have shown that expression of micoRNAs (miRNAs) is deregulated in human malignancies. MiR–122 is a miRNA that constitutes 70% of total miRNA in the liver, modulates the expression of the Hepatitis C Virus RNA by interacting with the 5´ noncoding region of the viral genome and has been suggested to play a crucial role in hepatocarcinogenesis. Since the miRNA expression profile has been proposed to be an important molecular prognostic marker of carcinogenesis, we studied the expression pattern of the liver specific miR–122 and of miR–198, shown by a screening assay to be dysre…
