CareLit Fachartikel
Sustained oxidative stress (H2O2) increases hepatic iron accumulation via translational stimulation of transferrin receptor 1 synthesis independent of the IRE/IRP network
B Andriopoulos, S Hegedüsch, J Mangin, J Wang, K Pantopoulos, S Mueller · Zeitschrift für Gastroenterologie · 2008 · Heft 01
Dokument
862826
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Jahr
2008
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Zusammenfassung
Aims: Various inflammatory conditions of the liver are associated with intracellular iron accumulation, e.g. in chronic hepatitis C and alcoholic steatohepatitis which are independent risk factors for disease progression and fibrosis. Previous work showed that the cellular iron master switch iron regulatory protein 1 (IRP1) is rapidly activated when cultured hepatocytes or the whole liver are exposed to H2O2. However, it is poorly understood how hepatic iron metabolism responds to sustained exposure of H2O2 which more likely represents pathophysiological oxidative stress conditions. METHODS AND Results: We emplo…
Schlagworte
HCV
alcoholic hepatitis
hydrogen peroxide
iron
oxidative stress
transferrin receptor
Zeitschrift für Gastroenterologie
