Tenofovir disoproxil fumarate in severe acute hepatitis B

Background and aim: Acute hepatitis B can progress to liver failure in about 1% of patients who may require liver transplantation. Lamivudine has been shown to be able to prevent acute liver failure and liver transplantation when administered early enough on the course of disease.Very recently, data on tenofovir disoproxil fumarate (TDF) were presented suggesting that this drug is one of the most promising alternatives for patients with chronic hepatitis B.We assessed the clinical value of TDF in patients with severe acute hepatitis B. Patients: Between June and December 2006, five (F: M=3/2; mean age: 34 ys) of…