Serum ceruloplasmin oxidase activity is a specific and non-invasive marker for Wilson disease

Objective: A low serum ceruloplasmin has long been considered a useful diagnostic test for Wilson disease. Because a biologically relevant parameter of ceruloplasmin is its oxidase activity, we aimed to evaluate an enzymatic test for ceruloplasmin in diagnosing Wilson disease. Design: Ten treatment-naïve and seventy-three treated Wilson disease patients were analyzed and compared to fifty-one healthy controls. Serum ceruloplasmin was measured immunologically and its oxidase activity enzymatically with o-dianisidine dihydrochloride as substrate. Results: In Wilson disease patients immunoreactive ceruloplasmin con…