In-vitro neuroprotective activity of Cynomorium songaricum extracts

In Traditional Chinese Medicine a number of herbs are used to alleviate age-related diseases including memory impairment and dementia, among them stems of Cynomorium songaricum, Cynomoriaceae. In this study, we evaluated the protective effect of different extracts of C. songaricum on amyloid-β peptide (Aβ), staurosporine, as well as hypoxanthine/xanthine oxidase induced cell death in SK-N-SH neuroblastoma cells. Aβ (20µM) as well as staurosporine (100 nM) both reduced cell viability to about 50–60%. The methanolic extract of C. songaricum attenuated Aβ induced cell death at concentrations of 100 and 10µg/ml, an…