Assessment of ipsilateral premotor-to-motor connectivity by highly focal TMS

Introduction: Bifocal transcranial magnetic stimulation (TMS) has been successfully used to examine interhemispheric interactions between motor cortical areas (e.g. transcallosal interhemispheric inhibition). So far, the large size of the transducing coils has precluded bifocal TMS of adjacent motor areas in the same hemisphere. We recently developed highly focal minicoils which enable bifocal TMS of two adjacent cortical areas. Using these minicoils, we studied cortico-cortical connectivity between left dorsal premotor cortex (PMd) and left primary motor hand area (M1-HAND) during movement selection. Methods: I…