An approach to identify synchronization clusters within the epileptic network

Introduction: Epileptiform activity is usually assumed to be associated with an increased synchronization of neuronal assemblies involved in the epileptic process. Indeed recent studies indicate that the EEG dynamics of the epileptic focus exhibits a higher degree of synchronization than the dynamics of remote brain areas, even during the interictal state. This would imply the existence of spatially extended synchronization clusters within the epileptic network, the most pronounced cluster describing the spatial-extent of the epileptic focus. We here investigate whether such synchronization clusters can be relia…