Diffusion Tensor Imaging of the Corpus Callosum distinguishes Parkinson's Disease from Corticobasal Syndrome

Background: The differentiation of Parkinson's Disease (PD) and Corticobasal Syndrome (CBS) is often a challenge for clinicans due to multiple overlapping features and symptome variability. No abnormalities of the widespread pathological changes in CBS are definite, but more objective measures are desirable to differentiate PD from CBS. Recently, the non-invasive assessment of white matter fibre bundles using MR diffusion tensor imaging (DTI) and analyzing diffusion parameters in the corpus callosum (CC) became available. This procedure provides new insights for the evalutaion of transcallosal connectivity in bo…