Does navigated transcranial magnetic stimulation (TMS) decrease the variability of MEP-amplitudes?

Introduction: One major attribute of transcranial magnetic stimulation (TMS) is the variability of the MEP-amplitudes. Navigated TMS allows the investigator to retrieve the stimulation site with an accuracy of 2.5 millimetres (Schönfeldt-Lecuona et al., 2005). The purpose of this study was to investigate the variability and reproducibility of MEP-amplitudes with and without navigated TMS at one point in time as well as the reproducibility between different points in time. Methods: We investigated n=8 healthy subjects (w: n=4, m: n=4; age: 22 to 25; mean age 23.8±1.24) at three different points in time (interval…